{"id":1327,"date":"2023-08-26T07:59:40","date_gmt":"2023-08-26T07:59:40","guid":{"rendered":"https:\/\/staging.breastaware.gr\/?page_id=1327"},"modified":"2025-08-10T08:20:27","modified_gmt":"2025-08-10T08:20:27","slug":"%ce%b5%ce%be%ce%b5%ce%b9%ce%b4%ce%b9%ce%ba%ce%b5%cf%85%ce%bc%ce%ad%ce%bd%ce%bf%ce%b9-%cf%80%cf%81%ce%bf%cf%83%cf%84%ce%b1%cf%84%ce%b5%cf%85%cf%84%ce%b9%ce%ba%ce%bf%ce%af-%cf%80%ce%b1%cf%81%ce%ac%ce%b3","status":"publish","type":"page","link":"https:\/\/staging.breastaware.gr\/en\/%ce%bf-%ce%bc%ce%b1%cf%83%cf%84%cf%8c%cf%82-%ce%bc%ce%bf%cf%85\/%ce%b5%ce%be%ce%b5%ce%b9%ce%b4%ce%b9%ce%ba%ce%b5%cf%85%ce%bc%ce%ad%ce%bd%ce%bf%ce%b9-%cf%80%cf%81%ce%bf%cf%83%cf%84%ce%b1%cf%84%ce%b5%cf%85%cf%84%ce%b9%ce%ba%ce%bf%ce%af-%cf%80%ce%b1%cf%81%ce%ac%ce%b3\/","title":{"rendered":"Specific Protective Factors"},"content":{"rendered":"
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\n\t

Specialized Preventive Measures for Breast Cancer<\/strong><\/p>\n

Protective Factors for High-Risk Women<\/strong><\/p>\n

Breast cancer is the most common cancer among women worldwide. Although most cases occur in women without a strong family history, some women belong to high-risk groups<\/strong> due to genetic mutations (BRCA1, BRCA2), family history, or individual risk factors.<\/p>\n

For these cases, there are specialized preventive interventions<\/strong> with documented efficacy, implemented exclusively after personalized evaluation by a multidisciplinary team (breast surgeon, oncologist, geneticist, psychologist).<\/p>\n

 <\/p>\n

    \n
  1. Chemoprevention<\/strong><\/li>\n<\/ol>\n

    The Chemoprevention<\/strong> involves the use of preventive pharmacological agents to reduce breast cancer risk in high-risk women.<\/p>\n

    The most commonly used medications are:<\/p>\n

      \n
    • Tamoxifen<\/strong> (for premenopausal and postmenopausal women)<\/li>\n<\/ul>\n
        \n
      • Raloxifene<\/strong> (for postmenopausal women)<\/li>\n<\/ul>\n

        The use of these medications can reduce the risk by 30\u201350%. However, they may cause adverse effects such as hot flashes, increased risk of thromboembolism, or endometrial cancer. The decision should be made in full medical guidance<\/strong>, weighing the benefits and risks.<\/p>\n

         <\/p>\n

          \n
        1. Prophylactic Mastectomy<\/strong><\/li>\n<\/ol>\n

          The Prophylactic mastectomy<\/strong> is the surgical removal of both breasts in women with genetic mutations such as BRCA1 or BRCA2.<\/p>\n

          Surgery can reduce the risk of developing breast cancer by 90\u201395%<\/strong>. Many women choose this measure as a means of prevention and psychological relief. It is often combined with breast reconstruction<\/strong>, offering improved aesthetic and psychological outcomes.<\/p>\n

           <\/p>\n

            \n
          1. Prophylactic Oophorectomy<\/strong><\/li>\n<\/ol>\n

            The Prophylactic removal of the ovaries and fallopian tubes<\/strong> (usually laparoscopically) significantly decreases estrogen production, which is implicated in hormone-dependent breast cancer development.<\/p>\n

            It is indicated for women with BRCA mutations, primarily after completion of childbearing.
            \nThe surgery reduces both the risk of breast cance<\/strong> as well as the risk of ovarian cancer<\/strong>. At the same time, it is associated with early menopause<\/strong> and effects such as hot flashes, mood disturbances, reduced bone density, and decreased fertility \u2014 therefore requiring multidisciplinary support.<\/strong><\/p>\n

             <\/p>\n

            Personalized Prevention: A Powerful Tool<\/strong><\/p>\n

            None of the above measures is appropriate for every woman. The individualized prevention<\/strong> is based on comprehensive medical assessment and respect for the woman\u2019s personal choices and values.<\/p>\n

            If you belong to a high-risk group, do not face it alone<\/strong>. Seek support from a specialized multidisciplinary team and learn about options that could save your life.<\/strong>.<\/p>\n

             <\/p>\n

            Learn More at breastaware.gr<\/strong><\/p>\n

            The breastaware.gr<\/i> is a reliable and contemporary online resource providing information on breast cancer<\/strong>, prevention, and care. With evidence-based content from experts, it empowers every woman to make informed health decisions.<\/p>\n

            \u00a0<\/span><\/p>\n

            Bibliography:<\/span><\/b>\u00a0<\/span><\/p>\n

            1.Cuzick J, Sestak I, Bonanni B, et al. Selective oestrogen receptor modulators in prevention of breast cancer: an updated meta-analysis of individual participant data. <\/span>Lancet<\/span><\/i>. 2013;381(9880):1827\u20131834.<\/span>
            \n2.<\/span> Rebbeck TR, Kauff ND, Domchek SM. Meta-analysis of risk reduction estimates associated with risk-reducing salpingo-oophorectomy in BRCA1 or BRCA2 mutation carriers. <\/span>J Natl Cancer Inst<\/span><\/i>. 2009;101(2):80\u201387.<\/span>
            \n3. Domchek SM, Friebel TM, Singer CF, et al. Association of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality. <\/span>JAMA<\/span><\/i>. 2010;304(9):967\u2013975.<\/span>\u00a0<\/span><\/p>\n<\/div>\n<\/div><\/div><\/div>

            <\/div>
            <\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"

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