{"id":1383,"date":"2023-08-26T08:11:14","date_gmt":"2023-08-26T08:11:14","guid":{"rendered":"https:\/\/staging.breastaware.gr\/?page_id=1383"},"modified":"2025-08-10T09:50:34","modified_gmt":"2025-08-10T09:50:34","slug":"%ce%bb%ce%bf%ce%b2%ce%b9%ce%b1%ce%ba%cf%8c-%ce%ba%ce%b1%cf%81%ce%ba%ce%af%ce%bd%cf%89%ce%bc%ce%b1-in-situlcis","status":"publish","type":"page","link":"https:\/\/staging.breastaware.gr\/en\/%cf%80%ce%b1%ce%b8%ce%ae%cf%83%ce%b5%ce%b9%cf%82\/%ce%bb%ce%bf%ce%b2%ce%b9%ce%b1%ce%ba%cf%8c-%ce%ba%ce%b1%cf%81%ce%ba%ce%af%ce%bd%cf%89%ce%bc%ce%b1-in-situlcis\/","title":{"rendered":"Lobular Carcinoma In Situ (LCIS)"},"content":{"rendered":"<div id=\"pl-1383\"  class=\"panel-layout\" ><div id=\"pg-1383-0\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-1383-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-1383-0-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><strong>Lobular Carcinoma In Situ (LCIS): Everything You Need to Know<\/strong><\/p>\n<p><strong>What is Lobular Carcinoma In Situ (LCIS)?<\/strong><\/p>\n<p>The <strong>Lobular Carcinoma In Situ (LCIS)<\/strong> is an alteration found in <strong>breast lobule<\/strong> \u2013 the areas where milk is produced. It is characterized by increased cell proliferation, which increases the risk of <strong>breast cancer<\/strong> up to ten times higher than the general population.<\/p>\n<p>Although it includes the term \"carcinoma\", LCIS <strong>not considered a true cancer<\/strong>, but <strong>increased risk indicator<\/strong>It can lead to the development of malignancy anywhere in both breasts, not necessarily in the area of the original diagnosis.<\/p>\n<p>The term \"<strong>in situ<\/strong>\" means that the damage <strong>remains within the lobes<\/strong> without extending into the surrounding tissues.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Who is affected by LCIS?<\/strong><\/p>\n<p>LCIS is <strong>rare<\/strong> and the average age of diagnosis is about <strong>45 years<\/strong>, with the <strong>80-90%<\/strong> of the cases to concern <strong>premenopausal women.<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p><strong>How does LCIS differ from Ductal Carcinoma In Situ (DCIS)?<\/strong><\/p>\n<p>It is important to distinguish LCIS from <strong>ductal carcinoma in situ (DCIS)<\/strong>. DCIS concerns the <strong>milk ducts<\/strong> and is considered a true, incipient cancer with a different treatment.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>What is the risk of developing breast cancer?<\/strong><\/p>\n<p>Womens with <strong>diagnosis of LCIS<\/strong> have:<\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><strong>lifetime relative risk from 8% to 30-40%<\/strong>, depending on factors such as age, family history and the presence of other high-risk lesions, compared to 12.5% in the general population.<\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><strong>About 20%<\/strong> probability within 15 years.<\/li>\n<\/ul>\n<p>The development of malignancy <strong>it is usually not immediate<\/strong> and it can happen <strong>10-20 years or even later<\/strong> after diagnosis.<\/p>\n<p><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone wp-image-1900\" src=\"https:\/\/staging.breastaware.gr\/wp-content\/uploads\/2023\/08\/\u03942\u03b2_\u039b\u039f\u0392\u0399\u0391\u039a\u039f-IN-SITU-\u03ba\u03b5\u03af\u03bc\u03b5\u03bd\u03bf11-1024x870-1-300x255.jpg\" alt=\"\" width=\"586\" height=\"498\" srcset=\"https:\/\/staging.breastaware.gr\/wp-content\/uploads\/2023\/08\/\u03942\u03b2_\u039b\u039f\u0392\u0399\u0391\u039a\u039f-IN-SITU-\u03ba\u03b5\u03af\u03bc\u03b5\u03bd\u03bf11-1024x870-1-300x255.jpg 300w, https:\/\/staging.breastaware.gr\/wp-content\/uploads\/2023\/08\/\u03942\u03b2_\u039b\u039f\u0392\u0399\u0391\u039a\u039f-IN-SITU-\u03ba\u03b5\u03af\u03bc\u03b5\u03bd\u03bf11-1024x870-1-768x653.jpg 768w, https:\/\/staging.breastaware.gr\/wp-content\/uploads\/2023\/08\/\u03942\u03b2_\u039b\u039f\u0392\u0399\u0391\u039a\u039f-IN-SITU-\u03ba\u03b5\u03af\u03bc\u03b5\u03bd\u03bf11-1024x870-1.jpg 1024w\" sizes=\"(max-width: 586px) 100vw, 586px\" \/><\/p>\n<p><strong>How is LCIS diagnosed?<\/strong><\/p>\n<p>The <strong>Lobular carcinoma in situ usually does not cause symptoms<\/strong> and has no special imaging features. It is often discovered <strong>randomly<\/strong> during <strong>biopsy<\/strong> performed for other reasons, such as a fibroadenoma.<\/p>\n<p>If suspected on mammography (e.g., due to calcifications):<\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"2\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\">It takes place <strong>core needle biopsy<\/strong> under local anesthesia.<\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"2\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\">In rare cases it is required <strong>surgical biopsy<\/strong> with general anesthesia.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><strong>What are the next steps after diagnosis?<\/strong><\/p>\n<p>If diagnosed by biopsy:<\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"3\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\">It is often recommended <strong>supplementary surgical resection<\/strong> for confirmation and complete removal of the area.<\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"3\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\">In cases <strong>of classic LCIS<\/strong> and with a low risk of underestimation (&lt;3%), it can be selected <strong>careful monitoring<\/strong> with regular check-up.<\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"3\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"3\" data-aria-level=\"1\">In cases of plural form <strong>LCIS or LCIS with necrosis<\/strong>, is recommended <strong>more aggressive diagnostic approach,<\/strong> due to a higher risk of coexisting malignancy.<\/li>\n<\/ul>\n<p>Decisions are always personalized in collaboration with a specialized breast surgeon.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>How can the risk of breast cancer be reduced?<\/strong><\/p>\n<p>For women with LCIS, there are ways <strong>risk reduction:<\/strong><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"4\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><strong>Endocrine Therapy<\/strong> with tamoxifen, raloxifene or aromatase inhibitors can reduce the risk of developing cancer by about <strong>50%.<\/strong> This choice should take into account the <strong>individual risk profile,<\/strong> <strong>the patient's age and possible side effects<\/strong>. Not recommended in all routine cases.<\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"4\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\">In special cases, it may be recommended <strong>prophylactic bilateral mastectomy<\/strong>, especially in women with <strong>strong family history or mutation in the BRCA1\/BRCA2 genes.<\/strong><\/li>\n<\/ul>\n<p>Because the <strong>Lobular carcinoma in situ is not an immediate threat<\/strong> and because many women will never develop cancer, each decision is made carefully and individually, after full discussion with the medical team.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Get Accurate Information at BreastAware.gr<\/strong><\/p>\n<p>At <strong>BreastAware.gr<\/strong> , you\u2019ll find reliable, scientifically validated, and user-friendly information on all breast diseases. Our goal is to empower you with knowledge and support for your health, focusing on prevention and early diagnosis.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Bibliography:<\/strong><\/p>\n<ol>\n<li data-leveltext=\"%1.\" data-font=\"Times New Roman\" data-listid=\"5\" data-list-defn-props=\"{&quot;335552541&quot;:0,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769242&quot;:[65533,0],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;%1.&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Baker+J&amp;cauthor_id=39270543\">Baker<\/a> J\u202f,\u202f<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Noguchi+N&amp;cauthor_id=39270543\">Noguch<\/a> N, et al. Atypical ductal or lobular hyperplasia, lobular carcinoma in-situ, flat epithelial atypia and breast cancer risk: A systematic review and meta-analysis. <i>Cancer Epidemiol.<\/i> 2024 Aug;86:102593.<\/li>\n<li data-leveltext=\"%1.\" data-font=\"Times New Roman\" data-listid=\"5\" data-list-defn-props=\"{&quot;335552541&quot;:0,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769242&quot;:[65533,0],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;%1.&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\">Update on Lobular Lesions of the Breast. <i>Pathol Res Pract.<\/i> 2023;237:154159.<\/li>\n<li data-leveltext=\"%1.\" data-font=\"Times New Roman\" data-listid=\"5\" data-list-defn-props=\"{&quot;335552541&quot;:0,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769242&quot;:[65533,0],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;%1.&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"3\" data-aria-level=\"1\">Harinath L,\u202f Villatoro\u202fT, et al. Upgrade Rates of Variant Lobular Carcinoma In Situ Compared to Classic Lobular Carcinoma In Situ: A Multi-Institutional Study. <i>Mod Pathol.<\/i> 2024;37(3):456\u2013464.<\/li>\n<li data-leveltext=\"%1.\" data-font=\"Times New Roman\" data-listid=\"5\" data-list-defn-props=\"{&quot;335552541&quot;:0,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769242&quot;:[65533,0],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;%1.&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"4\" data-aria-level=\"1\">Clinical guidance for the management of lobular carcinoma in situ. <i>Cancer Australia.<\/i> 2024 Nov 13.<\/li>\n<li data-leveltext=\"%1.\" data-font=\"Times New Roman\" data-listid=\"5\" data-list-defn-props=\"{&quot;335552541&quot;:0,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769242&quot;:[65533,0],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;%1.&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"5\" data-aria-level=\"1\">Surgical Management of Benign or High-Risk Lesions: A Consensus Statement from the American Society of Breast Surgeons. <i>ASBrS.<\/i> 2024 Mar.<\/li>\n<\/ol>\n<\/div>\n<\/div><\/div><\/div><div id=\"pgc-1383-0-1\"  class=\"panel-grid-cell\" ><div id=\"panel-1383-0-1-0\" class=\"so-panel widget panel-first-child\" data-index=\"1\" ><\/div><div id=\"panel-1383-0-1-1\" class=\"so-panel widget panel-last-child\" data-index=\"2\" ><div class=\"panel-widget-style panel-widget-style-for-1383-0-1-1\" ><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>\u039b\u03bf\u03b2\u03b9\u03b1\u03ba\u03cc \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03c9\u03bc\u03b1 In Situ (LCIS): \u038c\u03bb\u03b1 \u03cc\u03c3\u03b1 \u03a0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u0393\u03bd\u03c9\u03c1\u03af\u03b6\u03b5\u03c4\u03b5 \u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u039b\u03bf\u03b2\u03b9\u03b1\u03ba\u03cc \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03c9\u03bc\u03b1 In Situ (LCIS); \u03a4\u03bf \u03bb\u03bf\u03b2\u03b9\u03b1\u03ba\u03cc [&hellip;]<\/p>","protected":false},"author":1,"featured_media":1677,"parent":1411,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-1383","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/staging.breastaware.gr\/en\/wp-json\/wp\/v2\/pages\/1383","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.breastaware.gr\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/staging.breastaware.gr\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/staging.breastaware.gr\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.breastaware.gr\/en\/wp-json\/wp\/v2\/comments?post=1383"}],"version-history":[{"count":0,"href":"https:\/\/staging.breastaware.gr\/en\/wp-json\/wp\/v2\/pages\/1383\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/staging.breastaware.gr\/en\/wp-json\/wp\/v2\/pages\/1411"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/staging.breastaware.gr\/en\/wp-json\/wp\/v2\/media\/1677"}],"wp:attachment":[{"href":"https:\/\/staging.breastaware.gr\/en\/wp-json\/wp\/v2\/media?parent=1383"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}